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a-actinin Monoclonal Antibody

Price:
$69.00
SKU:
E-AB-22127-20
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Product Description

Product Name Cat# Clone# Isotype Applications Reactivity Unit/Size
a-actinin Monoclonal Antibody E-AB-22127 1D4 IgG IHC-p* Human,Mouse,Rat20μL, 60μL, 120μL, 200μL

Description

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.

Spec Sheet E-AB-22127 (PDF File)

Synonyms ACTN1
Swiss-Prot P12814
Concentration 1mg/mL
Host Mouse
Immunogen Recombinant Protein of a-actinin of ACTN1
Purification Method Protein A purification
Formulation PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Storage Store at -20?. Avoid freeze / thaw cycles.
Dilution IHC 1:100-200

Caution must be taken to avoid contact with skin or eyes. In such a case, rinse thoroughly at once with water. Do not ingest, inhale, or swallow. Seek medical attention immediately. Wear appropriate protective clothing such as laboratory overalls, safety glasses and gloves. It is strongly advised that this product should be handled by people who have been well trained in laboratory techniques and that it is handled with care pursuant to the principles of good laboratory practice. All chemicals are deemed potentially harmful. The vial is prone to fall over. Use caution, especially when the lid is off .

FOR RESEARCH USE ONLY, NOT FOR USE IN DIAGNOSTIC PROCEDURES.

* Remark Icon :

WB=Western Blotting, IP=Immunoprecipitation, IF=Immunofluorescence, IHC=Immunohistochemistory, IHC-p=Immunohistochemistory Paraffin, FCM=Flow Cytometry, CH=ChIP Assay

Manufactured by: Elabscience

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