Product Description
In a collaboration with Swedish CRO, we have developed a scaffold for stable, long-term co-culture of pancreatic cancer and stromal cells. Their model for pancreatic cancer co-cultures, a traditional submerged 2D system had performance issues. Limited space meant contact inhibition was problematic and the system became over confluent around 4 DIV, which was not enough time to develop a disease relevant culture.
The model is currently being used to further investigate drug sensitivity and cytotoxicity.
Cells Tested:
AsPc1
CAFs
| Validated readouts | Analytical methods |
| Cell morphology | Confocal microscopy |
| Cell infiltration | AlamarBlue® assay |
| Cell proliferation | ELISA |
| Biomarker expression | |
| Dose-response |
Specification and Comparisons
| Breast Cancer platform | Pancreatic Cancer platform | Neuro iPSC platform | Neuro HNPC platform | |
| Porosity | High | Medium | Low | Medium |
| Stiffness | Low | Low | Medium | Medium |
| Material | PCL | PCL | PCL | PCL |
| Cells tested |
L929(mouse) and human fibroblasts MCF-10A |
AsPc1 CAFs |
iPSC, iNeuron |
neuronal progenitor cells (HNPCs)
|
| Reference |
Permlid et al, 2019 |
Case study | Case study |
Zalis, 2016 |
FOR RESEARCH USE ONLY, NOT FOR USE IN DIAGNOSTIC PROCEDURES.
Manufactured by : Cellevate
|
Questions about this product? Email us at orders@iwai-chem.com or give us a call: (650) 486-1541 |
