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Anti-Human SMAD1

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Product Description

Product NameCat#Clone#Unit Size IsotypeApplicationsReactivity
Anti-Human SMAD1BMR00479913C1b 100ug/ml (1ml)IgG1DB,WB,IP,FC,ICCHu,Mo,Ra

* Background

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [NCBI Entrez Gene Summary]

*Quality of Control

BMR00479 WB Data

Data Sheet BMR00479 (PDF File)

Western blot protocol (PDF File)

Immunoprecipitation protocol (PDF File)

Flow cytometry protocol (PDF File)

Immunocytochemistry protocol (PDF File)

Antibody Concentration 100 ug/ml (1.0 ml)
Host SpeciesMouse
PreparationThis antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
SterilityFiltered through a 0.22 um membrane.
Alternate Names BSP1, JV41, JV4-1, MADH1, MADR1
Accession No.NM_005900

Caution must be taken to avoid contact with skin or eyes. In such a case, rinse thoroughly at once with water. Do not ingest, inhale, or swallow. Seek medical attention immediately. Wear appropriate protective clothing such as laboratory overalls, safety glasses and gloves. It is strongly advised that this product should be handled by people who have been well trained in laboratory techniques and that it is handled with care pursuant to the principles of good laboratory practice. All chemicals are deemed potentially harmful. The vial is prone to fall over. Use caution, especially when the lid is off .


Manufactured by : Bio Matrix Research, Inc.

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