Product Description
Product Name | Cat# | Clone# | Unit Size | Isotype | Applications | Reactivity |
Anti-Human STAT3 | BMR00237 | STAAD22A | 100ug/ml (1ml) | IgG1 | EL,WB,IP,FC,ICC | Hu,Mo,Ra |
* Background
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [NCBI Entrez Gene Summary]
*Quality of Control
Data Sheet BMR00237 (PDF File)
Western blot protocol (PDF File)
Immunoprecipitation protocol (PDF File)
Flow cytometry protocol (PDF File)
Immunocytochemistry protocol (PDF File)
Antibody Concentration | 100 ug/ml (1.0 ml) |
Host Species | Mouse |
Preparation | This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum. |
Sterility | Filtered through a 0.22 um membrane. |
Alternate Names | APRF, FLJ20882, MGC16063 |
Accession No. | BC000627 |
Caution must be taken to avoid contact with skin or eyes. In such a case, rinse thoroughly at once with water. Do not ingest, inhale, or swallow. Seek medical attention immediately. Wear appropriate protective clothing such as laboratory overalls, safety glasses and gloves. It is strongly advised that this product should be handled by people who have been well trained in laboratory techniques and that it is handled with care pursuant to the principles of good laboratory practice. All chemicals are deemed potentially harmful. The vial is prone to fall over. Use caution, especially when the lid is off .
FOR RESEARCH USE ONLY, NOT FOR USE IN DIAGNOSTIC PROCEDURES.
Manufactured by : Bio Matrix Research, Inc.
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